Since allergy medicines, including over-the-counter antihistamines, stop allergic reactions, you should not take them for a few days before the test. Talk to your doctor about discontinuing your allergy medicines prior to the test.
Your doctor will give you a list of medicines to avoid before the test, because there are other drugs that can interfere with the results. Since you may not be able to discontinue certain medicines, the doctor or nurse may perform a separate "control" test to determine if that particular drug will interfere with the scratch test.

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